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Th2 dominance

Dec 25, 2011

Would someone with Th2 dominace prior to HIV infection tend to have a worse prognosis compared to someone with Th2 dominace?

Response from Dr. Holodniy

It's a great question. I am not sure I could answer it, as I don't know what data there is where people have had their Th1 and Th2 characteristics identified before they are HIV infected and then again afterwards. Profiling these responses has certainly been done in people without HIV infection who have asthma and other diseases for example. As you may know there is a change in many people people from a primarily Th1 response (inflammatory/cytotoxic) to a Th2 response (anti-inflammatory) that has been implicated in HIV disease progression. Whether people who already have a predominant Th2 response and then become HIV infected progress more quickly, or whether HIV infection induces a change to a Th1 response after acute infection, even in those with a predominant Th2 pre-infection response is probably not known.

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