I recently saw my specialist for my quarterly blood work. Today he informed me that my ALT was unusually high (120). I have been on Atripla for nearly 8 years, and he suggested it may be time to change Sustiva for another medication, even though I'm not resistant to it. Could EFV be causing my ALT to rocket upwards after 8 years? I don't drink, don't do drugs, I'm celibate and have no risk factors for HCV, and I have had the series of shots and developed antibodies for HBV. Is there any reason why this is happening now? Any advice would be greatly appreciated.

This would be very unusual to occur as a result of taking Atripla after this many years. I assume other blood tests (liver enzymes, and yes, HCV and HBV tests) were performed. You also don't indicate whether you are taking any other prescription medications, over the counter products, herbs, etc. I don't think I would jump to changing medications yet., and just continue to watch, assuming everything else checks out.