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cd4 in atopic dermatitis
Sep 11, 2011

Hello Dr.

I have read that atopic dermatitis increases cd4/cd8 ratio. Will then dermatitis improve this ratio in a seropositive patient, increasing cd4 and decreasing cd8? Thank you for your time. Best regards

Response from Dr. Holodniy

Great question.Although an increase has been seen in people without HIV infection and in animals, the data on this with HIV infection is mixed. There is usually more atopic dermatitis (AD) in HIV infected than nonHIV-infected people. However, it is more often seen in people with advanced HIV infection where the CD4/CD8 ratio would be expected to be low because of the loss of CD4 cells in AIDS. So unlikely that AD itself improves the ratio or reduces the incidence of this in HIV infection. We do see a general decrease in skin disorders when people start HIV treatment and the CD4 count (and therefore ratio) improves significantly.



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