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Cd4+, CD8+, & total CD3 Avg has gone down while CD4+/CD8+ ratio has gone up
Sep 4, 2011

CD4+, CD8+ & total CD3+ values were 847, 1392, 2273 and CD4+/ CD8+ ratio was 0.61 respectively.

Now CD4+, CD8+ & total CD3+ values are 492, 662, 1155 and CD4+/CD8+ ratio is 0.74 respectively. Viral load is under undetectable range.

On one side the values of CD4+, CD8+ & CD3+ are going down while on other side CD4+/CD8+ ratio is increasing. I am confused that what it indicates exactly. Please clear the concept of these values and what it tells about the severity of the infection. Whether the results are promising as compared to earlier one? Please tell. Thank you for your time and consideration.

Response from Dr. Holodniy

For whatever reason your total t cell count (CD3) has decreased in half which has resulted in both your CD4 and CD8 counts (which are both t cells) in decreasing by half as well. That has resulted in a small increase in the ratio, as the CD4 decrease was less than the CD8 decrease. It is very unusual for the CD4 count (or the other cells for that matter) to drop so significantly in a short time, although you don't indicate how much time there has been between the two tests. Usually an acute fall occurs when there is some other type of infection or medical condition going and when that disappears the counts return to normal.



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