Resistant to most NRTI
Aug 7, 2011
Hello there, I been positive since 2001 and been taking Trivizir for 9+ years. CD4 count have been ranging from 350-550. Viral load: indetectable for straight 8 years. last month result were as follows: 550 CD4 and 20K viral load. Doctor ran a Phenotype test and I am now resistant to most NRTI (mutations: M41L, M184V, L210L/W and T215Y). Not sure what really happen here...
Response from Dr. Holodniy
Assuming no possible risk of recent transmission of a drug resistant strain of HIV, your virus has become resistant to the drugs in Trizivir. Your case is a bit unusual, in that we have usually seen failures with Trizivir much earlier in the course of taking it. Developing resistance after 9 years, particularly with a consistent undetectable viral load is unusual for any drug combination. All that said, there are many good options that you can switch to and get back to undetectable, but the combinations will likely be more complex as the drugs won't all be in the same pill.
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