|average cd4 loss per year
Sep 19, 2010
Dear Doctor, I read a medical research report which indicated the average annual NET loss of CD4s ( abs number),in the large majority of HIV positive people who do not take medication is approx 45. Nothing was mentioned about the average CD % drop. The finding appears to suggest that someone who let's say recovered back up to 500 CD4s after the initial infection drop , would be at 0 CD4s in about ten years post infection..without meds.. so the CD % would likely drop at a proportional rate, but just wondering about the validity of the absolute CD4 loss, based on what you've seen.. Thanks
| Response from Dr. Holodniy
Yes, that's about right. The natural history studies would suggest about a 50 cell decline per year or about 2-3% per year. Part of the equation though relates to the viral load level, the higher the viral load, the steeper the decline. Again, in the absence of any treatment.
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