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average cd4 loss per year
Sep 19, 2010

Dear Doctor, I read a medical research report which indicated the average annual NET loss of CD4s ( abs number),in the large majority of HIV positive people who do not take medication is approx 45. Nothing was mentioned about the average CD % drop. The finding appears to suggest that someone who let's say recovered back up to 500 CD4s after the initial infection drop , would be at 0 CD4s in about ten years post infection..without meds.. so the CD % would likely drop at a proportional rate, but just wondering about the validity of the absolute CD4 loss, based on what you've seen.. Thanks

Response from Dr. Holodniy

Yes, that's about right. The natural history studies would suggest about a 50 cell decline per year or about 2-3% per year. Part of the equation though relates to the viral load level, the higher the viral load, the steeper the decline. Again, in the absence of any treatment.



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