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cd8 higher without meds ?

Jun 27, 2010

Dr, I read that a highly elevated cd8 count and inverted ratio is a hallmark of hiv/aids and is present in 99% of the infected population, but also read that to be a good sign in that the cd8 cells are responding/fighting the infection. So the question is this: would the CD8 count be found to be generally much higher ( and the CD4 much lower ) in those individuals who do not take medication, but much more moderate and closer to an even ratio in those who are on meds ? I presume in spite of high CD8s being a "good thing" , it's still far more preferable to increase the CD4 count and percentage with the help of meds, but just wondering from a statistics point of view if the body naturally reacts by producing much more CD8s in the absence of meds ??

Response from Dr. Holodniy

It is more likely that the CD8 count would be higher without HIV meds, but this is not necessarily always the case.

follow up on resistance.
increase in cd4 and high vl load.

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