CD4 Slight decrease with Undetectable VL?
Apr 4, 2010
My VL went quickly to undetectable and my CD4 rose every three months from 190, 270, 350, 420, and then I didn't have testing done for 5 months. I just found out that my CD4 is at 400 now. I am confused as to why it didn't increase but actually dropped 20? I know this isn't a significant difference, and likely fits into the margin of error on most lab tests (<10%). I guess I am concerned that although I sustain an undetectable VL my CD4 will continue to decrease regardless.
Does this make sense seeing how I saw some fair gains already? Would the pattern reverse or is this just a blip? I am not sick and my physical health is excellent (eat well, take multivitamin and workout 4 times/week and run.
I also need to mention that I had an influenza vaccine within the 2-week period of blood work. Could this have affected the drop within a 2 week period of having the blood work?
Please let me know if this is something to be concerned about. I think that I am experiencing a disproportionate amount of stress over this.
Thank you for you time and consideration.
Response from Dr. Holodniy
I would not be concerned at all with that minimal decline in CD4 count, and yes, is likely within assay variation. You have had a fabulous response to HIV treatment. Your CD4 count has more than doubled, which is better than what is typically seen in most clinical trials. You may see a further but slower increase in CD4 count, but again, nothing to worry about. Just keep doing what you are doing.
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