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CD4 count up but CD4/CD8% all over the place
Dec 19, 2009

Hi. Since I got diagnosed my CD4 count has been steadily increasing from 213 - 325 over 6 months (not on meds yet). However the CD4-CD8% has been all over the place: 19%-24%-21% & last test 11%. I haven't been sick in any way I'm aware of, everything else is normal. Do you know of any reason why the % would fluctuate so much when the CD4 count is increasing (when supposed to be decreasing)? Very confused and uncertain. I got infected 3.5 years ago.

Response from Dr. Holodniy

That is a significant variation in CD4% that one normally does not see, unless there are other ongoing medical conditions, medications, or different assays for CD4 counts involved. I am not so concerned about the variation between 19-24%, but I am concerned about the 11% value. You don't indicate what your HIV viral load has been doing during this time. Regardless, given the CD4 count and percents, I would consider starting HIV treatment.



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