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Loss of HBeAg

Oct 31, 2009

My wife's HBV DNA count was 98 million copies/ml, HBeAg +ve (ELISA), AntiHBe -ve (competitive ELISA). Entecavir treatment was started. There was a relapse at 36 weeks. She was put on Pegasys 180 micro gm/week plus Adefovir Dipivoxil 10 mg/day. After 40 weeks of treatment, HBV DNA is 109 IU/ml, HBeAg -ve (ELISA), AntiHBE -ve (Competitive ELISA). What can be interpreted from the results? Is she clear from HBV or there are definite chances of relapse because of AntiHBE -ve ? Many thanks

Response from Dr. Holodniy

She has reponded well to the current treatment regimen and it is a good sign that the viral load is that low (but still detectable) and the e antigen is negative. She is not technically clear of the infection yet.

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