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Damaged virus

May 17, 2009

Is there a possibility to introduce into the system a modified but reproductive virus to force it's copies to be damaged or unable to enter healthy cells? Could this be a plausible and rational way to eliminate the virus from the body? I mean a corrupted virus should not be able to work properly like a computer programed for other purposes. Just asking. Maybe this sounds a bit crazy. Thanks for your attention.

Response from Dr. Holodniy

Excellent question. There have already been some attempts at this with gene transfer studies, where a weakened cousin of HIV has had genes inserted into the virus, introduced this virus into an HIV infected person's stem cells, which are then put back into the person, where they can become t cells to produce products that will decrease the replication of the regular HIV virus they are infected with. The problem is getting rid of the regular HIV virus which is hardcoded into the DNA of infected cells. From a strategy standpoint, it is easier to shut down the replication of existing HIV, but much harder to get rid of it permanently.

HIV 2 and progression to Aids

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