Non CD4 replication
Apr 5, 2009
HIV uses CD4 cells to replicate and is blocked by HAART from doing this explaining a VL UD when it's successful. But, is there any replication going on in the non CD4 cells that sequester HIV? like lymphnodes, and other tissues? and if so are these non CD4 host cells protected at all by HAART?
Response from Dr. Holodniy
Great question. First, there are CD4+ t cells and monocytes and other cells with CD4 receptors that exist in lymph nodes and other organs, and are not just circulating in the blood. HIV can infect some of these other types of cells and replicate at various levels. HIV meds to penetrate into these organs to affect HIV replication, but not all HIV drugs penetrate into all organs uniformly. So there are likely differences in drugs concentration and therefore activity of each HIV drug in a combo, say in places like the brain.
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