VL Significant Increase?
Feb 22, 2009
Hi, my blood results in Nov 08 were CD4: 785, VL: 18,388 (27%)and now Jan 09 CD4: 865, VL: 63,880. I'm quite concerned that my VL has increased by 45,492! yet my CD4 has increased by 80. Is this increase in VL significant (more than 3-fold)? I did not have any immunisations or illness around the time of testing - it has left me baffled. Any ideas? and what should my next steps be? Thank you.
Response from Dr. Holodniy
You are asking all the right questions. Given your normal CD4 count, I am not concerned with one value that shows this level of increase. If there are no medical reasons that we can find then it is still likely assay variability. Although the 3-fold rule is the average range for assay variability, it can be lower or higher than that. If there is a clinical reason to recheck, that is what I do. In your case, I don't think there is any reason to check sooner than your next scheduled visit.
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