|low WBC count and viread
Feb 8, 2009
OK, there has got to be a connection here. I have recently received my latest lab report and find that my wbc is now deficient. Looking back on previous lab work, I can now see a steady decline. Just searching this forum I have read 4 other posts regarding low wbc where the patient is on some form of viread/tenofovir and yet there is nobody has connected the dots? connect the dots.
| Response from Dr. Holodniy
In the registration studies for tenofovir, there was no real signal indicating that tenofovir caused a significant decrease in WBC or more specifically neutrophils compared to the other HIV regimens. That said, 1-3% did see a significant decline in neutrophils. In addition, the protease inhibitors Reyataz and Kaletra, increase blood tenofovir levels, which could potentially magnify a decrease in WBC in someone who is susceptible to a decrease in WBC while receiving tenofovir. Finally, combining tenofovir with videx (ddI) can definitely decrease the CD4 count significantly unless the videx dose is reduced.
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