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low WBC count and viread
Feb 8, 2009

OK, there has got to be a connection here. I have recently received my latest lab report and find that my wbc is now deficient. Looking back on previous lab work, I can now see a steady decline. Just searching this forum I have read 4 other posts regarding low wbc where the patient is on some form of viread/tenofovir and yet there is nobody has connected the dots? connect the dots.

Response from Dr. Holodniy

In the registration studies for tenofovir, there was no real signal indicating that tenofovir caused a significant decrease in WBC or more specifically neutrophils compared to the other HIV regimens. That said, 1-3% did see a significant decline in neutrophils. In addition, the protease inhibitors Reyataz and Kaletra, increase blood tenofovir levels, which could potentially magnify a decrease in WBC in someone who is susceptible to a decrease in WBC while receiving tenofovir. Finally, combining tenofovir with videx (ddI) can definitely decrease the CD4 count significantly unless the videx dose is reduced.



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