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Is it resistance?
Jan 25, 2009

Dear Sir, my dad's HBV DNA level is now 4,600,000copies/ml. He was a chronic carrier for 14 yrs and he took lamivudine for 7 yrs , adefovir for 1.5yrs.Last yr, his DNA level was 100,000,000copies/ml.And then, last 6mths, his level decreased to 2,600,000copies/ml.So, by taking these two drugs, his dna level increased fr. 2,600,000 to 4,500,000. So, is it resistance? His underlying liver is Early Cirrhosis and his ALT& AST level stills normal. when will his liver change malignancy?

Response from Dr. Holodniy

It could very well be that his virus has acquired resistance to these drugs. There are blood tests available that can help sort this out. Also there are blood tests and scans that can help determine the extent of liver injury or whether cancer may be present.



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