I have been HIV+ for 17 years and never had a CD4 count below 494. My lab results today were CD4 925 and undetectable viral load. My AST and ALT were elevated at 71 and 73 respectively. I have never had this finding in the past, always in the 20's and 30's. No new medications. I take Sustiva and Epzicom along with Actos 45mg, Crestor 10mg and Lovaza 2gm bid. I have partied a little to much over the last 6 months, but no IV drug use or unprotected sex. Can you help me shed light on this rise in LFT's? I am a little worried of fatty liver, but have no concern of HCV or HBV. Thanks in advance

Well, any one of the medications you are taking can cause an elevation in those liver enzyme tests. They are all metabolized by the liver, and when you combine taking so many medications that all need to go to the same place, you could have some interactions that are manifested by elevation of these tests. Although it requires watching, I am not that concerned, unless the numbers started creeping over 150 or so. Partying, particularly with alcohol, could also elevate those enzyme levels.