My CD4 numbers have slowly made it to 329. Been on many different regimens. CD4 started at 10, then over the past four years on same meds of Trizavir, Norvir, Lexiva numbers 10, 14, 60, 77, 241, 277, 329. Viral load undetectable all of this time. Still feel fatigue, ill feeling, diarrhea cronic (Cannot leave house), now they say triglycerides are high, also losing weight (10 - 15 lbs), not trying. Losing fat in arms, legs, butt. When do I change meds? Numbers seem good, but feel and look terrible. Thanks for your time. J

You have had a great response with that regimen, but it sounds like you need a change now. It is likely that the norvir/lexiva are causing the diarrhea and perhaps the lipid changes, and the fatigue could be related to chronic diarrhea (loss of electrolytes and nutrients) or the AZT in the trizivir. Some people and their doctors are reluctant to change meds because they are "working" relative to the virus. But changing meds when the viral load is undetectable is the best time. A change now to something like Atripla (3 meds in one pill once a day) may help your symptoms.