|Massive VL yet increasing CD4, WTF?
May 27, 2007
I was diagnosed HIV+ DEC 2006.
Since that time(six months) my VL has gone from 260,800 to 1,090,000, yet my CD4 count has risen slightly from 332(19%) to 445(21.1%).
All of my research thus far leads me to ask, how is this possible? Shouldn't VL change be inversely related to CD4 change?
I'm I just possibly misunderstanding an "economy of scale" thing, i.e. the rate of CD4 cell production by the body is based on many factors other than HIV alone?
I say this because I've been VERY aggressive in improving my general health through diet, exercise, and mental health. Are these "improvements" possibly temporarily off setting cell death from such a high VL, or are the test results really just statistically "the same" CD4 count?
I have M tropic subtype B (no drug resistant mutations), so CCR5-CD4 cells "should" be at highest risk for cell death, correct?
I started treatment just after the one million mark, so I understand that will "reset the picture" to a large degree, but this question is more for my education than "concern".
THANKS SO MUCH FOR THE WORK YOU GUYS DO FOR US!
| Response from Dr. Holodniy
Although that increase in absolute CD4 count appears to be significant, the fact that the CD4 percent only increased by 2%, does not make that change significant. The absolute CD4 count can change because of time of day, other ongoing infections, stress, immunizations, meds, among others. The CD4 percent is a more stable number over time.
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