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Progressive decline

Apr 22, 2007

Hi Mark,

I hgave a simple question which about what exactlky "progressive decline in CD4 counts" means in the CHRONIC phase of HIV infection where a patient is NOT yet under treatment.

My question is:

1) will this always mean a decline every six months (i.e. a straight line decline (though the gradient might change); OR

2) can some patient have peaks and troughs but the overall picture over 6 years (or so) is decline. (i.e. can one have a jagged line on a graph).

Hope this makes sense.

Response from Dr. Holodniy

Peaks and troughs is probably more the norm. CD4 count can be affected along the way by other medical conditions, stress, other infections, immunizations, meds, recreational drugs, among others.

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