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Does allergic reactions increase unwanted immune activation?

Mar 24, 2007

I understand that hiv disease involves excessive immune activation, which effectively burns out certain components of the immune system. It is also my understanding that allergic responses involve a type of unwanted immune activation. Is there a relationship between the two? Specifically, is it possible that heightened exposure to allergens might hasten the type of immune activation associated with hiv disease?

Response from Dr. Holodniy

Excellent question. There are other cells and mediators that are involved in allergic responses in addition to the cells involved in HIV infection. I don't know that we have a good answer for your question and whether HIV disease progression is accelerated in those with chronic environmental allergies.

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