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TDM-saquinavir/r once daily
Dec 17, 2006

Dear Dr., My question is about the utility of TDM. I am about to switch from unboosted Fortovase 2*1600 to Invirase/r once daily (2000/100 or 1500/100 - because of the convenience of once daily dosage) and was thinking of performing TDM - two tests while still on Fortovase (one week apart) and two tests afterwords (one week apart). 2 questions: 1. Any comment on once daily saquinavir/r vs twice daily would be greatly appreciated; 2. Does this scheme of performing TDM make any sense to you?

Thanks a lot for your help

Response from Dr. Holodniy

Assuming your HIV viral load is undetectable, I don't think you need to do the TDM. You could just convert to a boosted saquinavir regimen. Although you don't indicate what your other HIV meds are, you might want to consider atazanavir(Reyataz)(300mg)/r(100mg), which would be 2 pills once a day, or Kaletra (lopinavir 200mg)/r(50mg)- 4 pills one a day.



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