|Meaning of Helper / Suppressor Ratio
Nov 25, 2006
I've been tracking my labs over the last nine months since I found out I was HIV positive, and understand all of them except the helper/suppressor ratio. When I look it up I just get a simple definition, but am wondering which way, directionally, is better? In other words, is it better if it's less than 1.0 or if it's greater, and why is that?
| Response from Dr. Holodniy
In general, in someone without HIV infection the CD4/CD8 ratio is between 1 and 2. With HIV infection, 2 things are happening, the CD4 cell count goes down and the CD8 cell count goes up. Both of those aspects contribute to a decreasing ratio that is usually < 1 with HIV infection, although not always.
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