Forum on Understanding Your Labs: aptivus & prezista

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aptivus & prezista
Oct 7, 2006

what are the mutations these drugs are resistant to?

Response from Dr. Holodniy

They are long lists. The mutations associated with tipranvir (Aptivus) include: L33F, V82T, I84V, L90M. Others that can affect susceptibility include: L10V, I13V, K20R, E35G, M36I, K43T, M46L, I47V, I54A, Q58E, H69K, T74P, N83D. Mutations associated with darunavir (Prezista) resistance are still preliminary. Mutations that may be significant include: V11I, V32I, L33F, I47V, I50V, I54M, G73S, L76V, I84V, and L89V.

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