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GI RN looking to convert IU/mL to copies/mL

May 20, 2006

I'm an RN who after 8 years of working on an ortho/surgical unit, started working in private practice for a GI doc 4 mos. ago. I'm learning so many new things, and I am enjoying this new adventure in my career. After much on-line searching, I am still having trouble trying to figure out this conversion. I'm looking for an easy way to convert IU/mL to copies/mL as well as LOG IU/mL to copies/mL. These are actual lab results for HCV RNA QN, PCR...19.4E6 (ref <50 IU/mL) and 7.29 (ref <1.70 LOG IU/mL. Could you please help me convert these results to copies/mL? Thank you for your time. DM, R.N.

Response from Dr. Holodniy

In tests using Polymerase Chain Reaction (PCR) technology: Copies/mL = IU/mL x 2.7 In tests using Branched DNA(bDNA) technology: IU/mL = Copies/mL x 5.2.

In your example, 19,400,000 IU/ml = 52,380,000 copies/ml. Then convert to log10 IU or copies. In your example, 19,400,000 IU/ml = 7.28log10 IU/ml or 7.71 log10 copies/ml.

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