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non-viable HIV?
Apr 1, 2006

What does that mean? I understand what the English words mean, but how can some of it be not able to replicate? How transmitted? CD8s still respond, but are there studies about what percentage is non-viable and how that relates to long term outcomes?

Response from Dr. Holodniy

Older study estimates indicate that one in a thousand viral particles produced are infectious, or able to infect other t cells. Because the virus makes mistakes when it copies itself, many of the particles are defective, and although produced are unable to infect cells. We don't have any good clinical studies to know how variable in people the ratio of viable to nonviable viruses is, or whether it affects outcome.



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