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Immune Reconstitution

Jan 28, 2006

I was diagnosed with HIV on November 11, 2005. On November 22 I got my results back which showed a 203 T Cell and 12,000 VL no drug resistance.

I went on Sustiva and Truvada immediately. Now 8 weeks later I am at 357 TCell and 617 VL. However lately I have been feeling sick, severe night sweats and diarrhea. I seemed to have developed a small lesion on my upper left shoulder. I was reading about Immune Reconstitution in which the body actually is getting better but may trigger some responses when the immune system is actually improving. I have a doctors appt in about a week and am kind of concerned. Is it possible to experience IRIS so quickly? Thank you.

Response from Dr. Holodniy

You have had a great treatment response. Immune reconstitution inflammatory syndrome or IRIS can occur within a few weeks of starting HIV treatment and usually in people with much lower CD4 counts than what you started with. Your symptoms don't sound like side effects from your meds. It is possible you have some other kind of infection going. And getting it checked out this coming week is appropriate.

Dr confused

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