Dec 24, 2005
diagnosed in 1994 with cd4=3.viral load 289000.took azt alone for short time the 3tc with d4t alone for another short time.then invirase and viracept,after all that sustiva+ziagen+VIDEX+3TC DID ME good went down to around 40000 vl cd4 went up to around 123,then we switched to kaletra+viread+videx+3TC.this combo for 3 years kept me at vl<700 and cd4 went up 3350 range.6 month ago i got 2 UD vl tests with cd4 380,and 367 respectively,at that time me and my doctor decided to switch to easier regimn lexiva+truvada_ziagen,but during those 6 month my viral load has gone up to 50000,so i have partial resistance to lexiva and total resistance to ziagn.resistance test shows my virus is senstive to kaletra,crixivan,viread,videx,d4t,so now i have been switched to kaletra+crixivan800mg bid along with truvada.resistance tests shows am still very sensitive to kaletra which i stopped 6 month ago obvously a mistake,my viral load now on lexiva(boosted)ziagn+truvada,is 29000 and cd4 388,what are the cahnces that the kaletra will work again combined with crixivan and truvada,or is the 6 month away from kaletra and on lexiva has jeoprodized my senstivty to to kaletra.sounds confusing but i want to know if a combo of kaletra+crixivan+truvada which all show that i am senstive to all 3will be sufficient to go back to undet,vl.cause i never heard of that combination before ,and whats the right crixvan dosage with kaltra?thank you very much for any insight.james.
| Response from Dr. Holodniy
Teh devil is in the details of the resistance test report. First whether you got a genotype or a phenotype test and what the results actually say. Given your complex history, I could not comment on the appropriateness of the new regimen without having those test results in front of me.
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