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What does it mean to have the genetic marker HLAB-27?
Sep 25, 2005

I've been tested and shown positive. The doctor thinks I have ankylosing spondylitis as I show systems? Please explain this HLAB-27 marker and how it can be treated if another disease is present in the body?

Response from Dr. Holodniy

Human Leukocyte Antigen B27 (HLA-B27) is a genetic marker of AS. There are many people with B27 that do not get AS. About 5% with B27 get AS. Most people with AS have B27. It is thought that HLA-B27 interacts with other proteins in the body, affecting the body's normal immune response. Treatment is symptomatic with nonsteroidal antiinflammatory drugs like motrin.



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