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HIV RNA/DNA
Mar 28, 2001

Dr. Holodniy, I am curious. HIV-1 RNA or DNA sequence, does it resemble any other viruses, or specific cell type especially from humans. False positives in PCR tests, can it be due to RNA/DNA similarity at certain portions of the sequence. And PCR HIV-2 does not exist. Why can't we determine HIV-2 sequence, and HIV-2 sequence, is it vastly different than HIV-1 sequence?

Response from Dr. Holodniy

The virus is very unlike other viruses. HIV-2 has about 60% of it's sequence the same as HIV-1. False positives are most likely due to operator/technical issues and not sequence homology to other pieces of DNA.



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