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Subtypes and Coreceptors
Jun 13, 2005

Hi. I have read that a coreceptor switch is more likely in individuals infected with HIV subtype B than subtype C. Doesn't this difference mean that corecetpor targeting drugs may have to be used od designed differently for the two subtypes? Is there a difference in the number of CD4 cells especially macrophages or levels of CD8 cells between individuals infected with HIV-1 subtype C and subtype B.

Thank you

Response from Dr. Holodniy

I am not sure we have enough information yet about coreceptor usage and subtype. I do not believe there is a difference in overall cell number between subtypes.



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