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Your answers on HLA phenotypes: fascinating!
Apr 29, 2005

Fascinating answers on HLA phenotypes, Dr. Holodniy! So, does one understand correctly that, for HLA B-35 or B-37 to be predictive of disease acceleration, it must be inherited from both mother and father sides of the family? And that, even if it's just from one parent, that child will be listed as B-35 among his/her phenotypes, but it's a more benign B-35?

Is this a correct understanding? This research must be complex in that one has to get blood from both parents of an HLA B-35 child to see if it is from both and therefore more likelt to cause HIV acceleration?

Thank you!

Response from Dr. Holodniy

Like everything else with this infection, possibly. Here is another type of example. Some people have been found to have a CCR5 receptor (a secondary cell receptor that HIV attaches to with CD4) that has a DNA deletion that affects whether cells are HIV infected or not and whether people progress with HIV disease or not. If you are homozygous for the deletion, HIV infection is unlikely. If you are heterozygous for the deletion (one deleted and one normal gene sequence) you will get infected but tend to progress slower. If you are homozygous for 2 normal genes HIV infection occurs normally.



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