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Herpes attack/CD4's and accelerated HIV progression?

Mar 19, 2005

Hi, Dr. Holodniy;

HIV poz for 4 years, CD4's >650 usually, and up to 1,000 two weeks ago. CD4 percentage 46 percent, higher than usual 40%.

It turns out that I have just had a herpes attack for the first time since becoming HIV positive 4 years ago. My Q is, do CD4's and CD8's elevate when one has active herpes (could that explain the recent higher CD4 number and percent?) - and, if CD4's do go up, does that mean HIV could progress faster and CD4's decline faster because there are more CD4's for the virus to attack?

Thank you.

Response from Dr. Holodniy

The general trend is for CD4 counts to go down and HIV viral load to up with an acute outbreak, particularly in those patients not on HIV treatment. It is unlikely that the CD4 increase you have experienced will result in faster HIV progression.

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