viral replication assay
Jan 29, 2005
Can you tell me if and when you use the viral replication assay and how important has this test become? Is it essential to figure out the next regimen for someone who has been on multiple regimens?
Response from Dr. Holodniy
I believe you mean replication capacity (RC) assay, which has up to this point been included with a phenotypic resistance test from one of the companies that provides such tests. Preliminary studies suggest that a low RC might predict slower progression, or perhaps less urgency to change treatment in the face of lots of HIV drug resistance. The test is still being validated. In many cases it confirms what we suspect, namely that in those patients with detectable viral loads, stable CD4 counts and lots of drug resistance, the RC is usually very low, and these types of patients can be maintained on HIV meds to which their virus might be resistant.
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