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CD4 is barely moving

Dec 5, 2004

Dr. Holodniy, I was diagnosed Sept. 2002. Base Line VL was 38,914 and CD4 was 26/4%. Regimen for about one year is Viread, Epivir and Viramune. VL <50 since 2/03, as of 10-27-04, CD4 is only 30/10%. CD4 best was 69/12% two months ago. I am a 59 year old male. I have had pneumocystis, thrush/candidiasis, eosinophilic folliculitis, and suffer from fatigue and depression, but believe my general health is good. Started out with kaletra and combivir (switched due primarily to diarrhea). My doctor was very good but left for a teaching position; so I have a new ID doctor. How would you evealuate my situation, medication, and any other suggestions?

Response from Dr. Holodniy

Sounds like you have had a great virologic response, but your CD4 cells have not increased that much. Your percentage is significantly higher than before you started treatment. I suspect that your total white blood cell (WBC) and/or lymphocyte is much lower than the normal range. This could be due to other medications you might be taking, the relatively advanced HIV infection you had before you started treatment or some other infection affecting the bone marrow where blood cells are made.

CD4 dropping
Time Zone Re-dosing

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