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Lymphocyte count and CD4
Nov 3, 2004

Dear Dr. Holodniy

My wife is presently on Lamivudine, Zidovudine and Nevirapine. Her baseline CD4 was 83 and viral load 2071. CD4% was 13%. After 1 week of treatment, her WBC was 3900 and lymphocyte % at 33.5%. After 4 weeks, her WBC was 4000 and lymphocyte % was 36%. Thus total lymphocyte count had gone up from 1307 (after 1 weeks) to 1440 (after 4 weeks). Here in India, doctors prefer to regularly monitor progress through complete blood count, leaving more expensive CD4 tests for every 2-3 months. I understand that increased total lymphocyte count may be a sign of improvement in CD4. Is it reasonable to assume that CD4% would have improved, and CD4 count would also have improved (assuming unchanged CD4% of 13%). Kindly help an extremely concerned husband in India

Response from Dr. Holodniy

Your assumptions are reasonable.



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