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genetic variation and lab results in different people
Oct 10, 2004

This site, and experience, make it clear that there are huge variations between individuals in every aspect of HIV: how fast CD4s and viral loads change in the absence of therapy, whether they change at the same time, how well and how long the patient responds to therapy. We know from studies that the speed of progression is closely related to genetic markers such as what type of HLA you have. And there are geneticc tests that help to predict responses to medications such as nevirapine/viramune. Wouldn't it be helpful to get gene testing as part of the process?

Response from Dr. Holodniy

I agree that the HLA studies have been useful in helping determine those that were a greater risk of progression. However, these have for the most part been retrospective studies were the outcomes are known. The clinical utility of these tests would require prospective clinical trials were the HLA information was used to make treatment decisions and then patients followed prospectively for clinical outcomes.



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