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Explain CD8 Lymphocytes

Aug 15, 2004

What do CD8 Suppressors do?What does Red cell Distribution Width (RDW) mean & what does a high RDW mean. My RDW=21.6(H) [11.7-15]. WBC=5.3 [4.0-10.5] RBC=4.19 [4.1-5.6] HCT & HGB WNL Lymphs=49(H) [14-46] CD4 (Abs)=863 [359-1519] CD4 (%)=33.2 [30.8-58.5] CD8 (Abs)=928(H) [109-897] CD8 (%)=35.7(H) [12.0-35.5] thus: CD4/CD8 Ratio=0.92 WNL All other CBC values are WNL as were all values of UA (W/o sed) and a 14 point Metabolic/Chem panel. Also, my total testosterone=162(L) [241-827]. If CD4s & CD8s are labeled helpers & are CD3s labeled & what is their function? I've been on: A BID dose of 3TC 150MG AZT 300MG nevirapine 400MG for 12 weeks. My VL started at 298k & my CD4 (Abs) at 537. My VL isn't yet back but I'm please with a CD4 jump of 61 % in 12 weeks but confused about the high CD8s as well as their function. Thanks!

Response from Dr. Holodniy

CD3 measures the number of t cells, which are primarily composed of t helper cells (CD3CD4) and t suppressor/cytotoxic cells (Cd4CD8) cells. An elevation of CD8 count is a natural response to HIV infection in general. These cells provide the primary immune response against HIV. So this elevation is not unusual. The RDW measures the size distribution of red blood cells and probably elevated in you because you are taking AZT.

Effect of syphilis on CD4 count
undetectable but falling cd4

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