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rapid CD4 decline in primary infection
Jul 14, 2004

Five weeks after I was infected my CD4s were 807 and CD8s 497. Two weeks later my CD4s were 410 (40%) and CD8s 391 (29%) (total lymphocytes unchanged at1.7). Very scared. What does this mean for progression?

Response from Dr. Holodniy

CD4 counts can drop dramatically during acute infection and usually recover to some higher level after the very high levels of HIV found in the body are controlled by the immune system. Your CD4 percentage is in the normal range, although the absolute number appears to have decreased significantly. I don't think you can say anything aabout progression at this point. I would expect your numbers to level out and the absolute number to increase over the next few weeks based on your percentage.



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