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Resistance is Futile U Will be Assimulated!
Jun 14, 2004

I been infected for over 15 years hold agreat body weight and strength base line 68k and never higher than 32k. Recently after leaving a STI for 24 months i went on kaletra/verad: kaletra was intolerable in side effects recently switched to reyataz/norvir and viread, my Doctor shows concern for the fact that my viral load never dips below 150. copies or 75 undectable This new regime is fabulous and very easy. After reading the conferance reports on the SASH study i wondered why hiv therapies do not attempt to revisit this use of drug rotation to offset resistance?

Since hiv mutates why not see the glass as half full instead of half empty, develope drugs by computer genetic design that mutate the virus to benign state so the virus lives at low level in the blood for extended periods of time, or rather a simbiate relationship to the host, instead of protecting t cells let the virus replicate in a chemically dsigned HARTT enviorment that renders the virus inept, but ever present.

Please don't laugh at this analogy: In the series Star Trek the enterprise engineer rotates the shield harmonics of the ship rapidly rendering the attack of the Borg vessel useless as wellas immulogical treatment of the crew members immune cells letting the nanoprobes by the borg useless in the human host, but ever present, please don't laugh sometimes solutions come from other views, outside the box or rather the t-cell.

Response from Dr. Holodniy

Love the Star Trek analogy. We do this to a small extent today in some of the people we care for. Most resistance comes at a cost to the virus in terms of it's ability to replicate and kill t cells. Some mutations or combinations of mutations are particularly compromising and their effect can be measured by the replication capacity (RC) assay. Thus, keeping people on some medications they are resistant to can be clinically beneficial.



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