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Different Hep B Lab results
Apr 11, 2004

Dear Dr.Holodniy,

My ID specialist did some Hepatitis B tests, one was positive (reactive) the rest negative/normal. Can you please help me understand what this all means?

Specifically, the results appear as follows:

HB E AG Negative HB E AB Negative

HB S AG W/REFLEX CONF HB S AG 0.28 (normal 0-.79) HB CORE AB, TOTAL Negative

HB S AB, QL *HB S AB Reactive (Abnormal)

HB CORE AB (IGM) Negative

Can you please explain what it means that the one result above is reactive/abnormal and the rest negative...do I have Hep B or did I have Hep B?....

Many thanks.

Response from Dr. Holodniy

This pattern is typical of people who received a hepatitis B vaccine, where the surface antibody is the only thing positive. Most people with naturally acquired infection and subsequent immunity would also should core and/or e antibody positive as well.



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