|Circadian effect on CD4 and B cells
Apr 5, 2004
If one has blood drawn for a T cell subset at 11:30AM and it shows 950 CD4 cells and a CD4 percentage of 42 plus B cells of 250, are those numbers very likely to be higher if the blood had been drawn at 4:30PM? Are there many more CD4 cells and B cells in blood in the late afternoon than in the late morning and, if so, any studies or estimate of average increases?
| Response from Dr. Holodniy
There are not alot of studies looking at this question. In general, blood cells will be lowest in the early morning (5-7am) and highest in late afternoon. This has not been studied extensively, so it is not clear how much stage of HIV disease, gender, age, ethnicity, HIV treatment and a myriad of other variables might affect this.
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