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Circadian effect on CD4 and B cells

Apr 5, 2004

If one has blood drawn for a T cell subset at 11:30AM and it shows 950 CD4 cells and a CD4 percentage of 42 plus B cells of 250, are those numbers very likely to be higher if the blood had been drawn at 4:30PM? Are there many more CD4 cells and B cells in blood in the late afternoon than in the late morning and, if so, any studies or estimate of average increases?

Thank you.

Response from Dr. Holodniy

There are not alot of studies looking at this question. In general, blood cells will be lowest in the early morning (5-7am) and highest in late afternoon. This has not been studied extensively, so it is not clear how much stage of HIV disease, gender, age, ethnicity, HIV treatment and a myriad of other variables might affect this.

Thrush: HAART?

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