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Do CD4's go up or down upon 'flu vaccination or acute infection?
Dec 28, 2003

Dr. Holodniy,

I have two questions and would appreciate your advice -

1. Has anyone studied how the 'flu vaccine affects T cells from the time of vaccination till a month later? If so, what is the trend?... do CD4 cells go up upon vaccination and stay temporarily up for a month or do the CD4's go down on vaccination and stay down for a month? Would you expect a temporarily increased or decreased number of CD4 cells and CD4 percentage 10-14 days after vaccination?

2. Do CD4 cells increase or decrease when someone has an acute infection and the immune system responds?

Many thanks. Happy holidays!

Response from Dr. Holodniy

The published data in HIV infected patients around this issue is conflicting. Some studies show increases and others show decreases. This probably relates to the different populations and timing of samples. The change in CD4 count and viral loads with a real influenza infection or vaccine are dependent on what someones CD4 count and viral load is, whether they are on HIV treatment.



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