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Visual Changes in Early HIV Infection
Mar 15, 2001

Dr. Holodniy, I've recognized, through HIV-related discussions and internet readings, that many HIV+ patients develop floaters (vitreous fiber condensation 'cobweb type') in early HIV infection.

I believe this is because of the immune system's recovery after ARS and the associated inflammatory response. This condition seems to be similar to documented HIV uveitis experienced by HIV patients after initiating HAART.

My hypothesis is that the occurence of multi-focal cobweb-like floaters after ARS, in treatment naive HIV+ patients, is caused by the inflammatory response associated with immune system reconstitution after ARS.

Your thoughts please.

DISCLAIMER: I understand that floaters are, nonspecific develops and a common part of the aging process and that HIV- as well as HIV+ develop them.

Response from Dr. Holodniy

Your hypothesis is possible. We could only prove that by sampling cells within the vitreous and studying their level of immune activation. MH



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