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rate of mutation

Jun 14, 2003

Dr. Holodniy, what is the rate of mutation in any given viral transcription cycle. also could you please inform me of the number of viral particles rpoduced in a day?

Response from Dr. Holodniy

The absolute, actual number is not known. But studies and mathematical modeling suggests that one base error occurs for every copy of virus made. This is about 1 mutation per 10,000 nucleotides. The estimated production of viral particles per day in someone who is not on treatment is estimated to be about 500 million to 1 billion per day.

Normal drop of CD4?
reduced B cell expression

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