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vaccination and HIV viral load

Jun 14, 2003

Does the same immune response occur in a vaccination and an infection? Are the same cell sunsets activated in a vaccine to induce an immune response that are activated in response to an infection? Why do HIV viral loads rise in a patient during a vaccination series?

Response from Dr. Holodniy

This is a great question. Most vaccines do induce a specific immune response against the antigens contained in the vaccine. However, there is also some nonspecific activation that occurs, which in turn will activate CD4 cells that contain HIV, and HIV replication can then occur. This is usually blunted or nonexistent in people on HIV meds, which shuts HIV replication down, even in the presence of another stimulant like a vaccine.

cd4's as high as they can get in 3 months?
Normal drop of CD4?

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