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Immune function
Jun 7, 2003

Dr. Holodniy, Besides T cell and IgG subsets, what other tests are there to determine the strength of one's immune system...ability to fight off viruses and bacteria? Could low IgG (or a low level of other non-CD4 immune cells)cause a virus such as CMV, HSV, EBV to become chronically active...even with a normal level of CD4 cells? If so, what is the treatment to help the body suppress the chronic infection (since HAART seems targeted on restoring just CD4 cells)?

I would really appreciate your insights. Thanks.

Response from Dr. Holodniy

T lymphocytes are the predominant cell type the body uses to fight and contain these viral infections. B cells produce antibodies and are a secondary containment system. For awhile, HIV infection often results in more antibodies in general being produced. Studies have been conducted giving immunoglobulin to HIV patients, but there does not appear to much added value in this strategy over and above HAART.



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