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How to determine Baseline?
May 25, 2003

Hi and thank you in advance for you help. I am currently seroconverting and have had 3 sets of labs completed. My question is what would be considered my baseline number and over all how does my numbers and treatment look? If possible should I expect to move to a undetectable? I had been on med one week when the last labs were drawn. I am on Viread, Epivir,Viramune and Kaletra.

04/23/03 CD4 - 699 VL - 1,600,000 HIV Antibody - Negative

05/06/03 CD4 - 682 CD4/CD8 Ratio - .35 VL - 1,040,000

05/14/03 CD4 - 899 CD4/CD8 Ratio - .62 VL - 13,800

Thanks again.

Response from Dr. Holodniy

This is a difficult question to answer in you since you have already started therapy. We don't usually associate the viral loads during acute infection with someone's baseline viral load. The conventional definition is usually defined after someone has seroconverted and reached their own "setpoint" viral load during early chronic infection. Given that regimen, I would expect your viral load to reach an undetectable level within the next few weeks.



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