May 25, 2003
i need help understanding lymphocyte subsets. can u help me understand the following? my labs say: TLymphs(cd3+/cD45+) 84;count:2536 THelper(cd3+cd4+/cd45+) 27;count:815 TSuppressor(cd3+cd8+/cd45+) 55; 1661 HelperT/Suppressor T Ratio = 0.5 BLymphs (cd19+/cd45+) = 7.0 NKLymphs (cd16+cd56+/cd45A+) = 7.0 I understand from my doctor that my cd4 (815count/27) is good,and that my viral load, which is 3123 is also good. but i DO NOT understand the rest. i received this report in late april. when do you suggest i go for another lab report?
Response from Dr. Holodniy
It's like peeling the layers off an onion. If you start with the total white blood cell (WBC) count, the major cells in the differential are neutrophils, lymphocytes and monocytes. Of the lymphocytes, they come in two basic varieties, B cell lymphocytes (CD19, which make antibodies), and t cell lymphocytes (which are involved in cell-mediated immune responses). The t cells (CD3 cells) are divided into the t helper (CD4 cells) and t suppressor/cytotoxic (CD8) cells. Natural killer cells are a slightly different kind of cell involved in recognizing infectious agents, and cells infected with them.
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