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Are Regained T-Cells Weaker?
May 11, 2003

Is there much difference between three people who each currently have 500 CD4 cells if the first person made a slow climb from 25 to 500, while the second person climbed from 200 to 500, and the third person has never gone below 500?

Would you expect to see much difference in immune function between these three individuals? Are their 500 CD4 cells all equal, or would the person who had to regain the most CD4 cells (via meds) have weaker CD4 cells?

Response from Dr. Holodniy

500 CD4 cells are not all created equal. Someone at 500, who never decreased is probably in the best shape. Someone who goes from 20 to 500, recovers a significant enough number of clones to protect them from very serious infections, but perhaps not all of them. The 200 to 500 guy, is somewhere in the middle.



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