how do depleted numbers of CD4 cells affect antibody production
Apr 20, 2003
how do depleted numbers of CD4 cells affect antibody production and cell mediated immunity?
what affect do antibodies have on the numbers of HIV particles?
Response from Dr. Holodniy
CD4 cells make lots of chemicals and hormones that are required for normal function of b cells and cytotoxic t cells (CD8 cells). Thus, if their number is decreased significantly, these other cells are not signalled appropriately to perform their functions. Although not the primary immune response to HIV infection, antibodies are produced against the virus which "neutralize" viral particles. Neutralization essentially coats viral particles in circulation or lymph nodes rendering these particles "noninfectious" and allows the lymphoid tissue to destroy the virus.
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